Tg Anh Ho Van Hien,
Rat cam on anh da gop y cho ve van de pH trong sua me. Toi xin ghi nhan va chinh sua cho chinh xac. Chung ta la ban dong mon, cung tot nghiep “Y khoa Dai hoc duong Saigon”, do vay, xin coi nhau la dong nghiep, anh em. Anh dung goi toi la Bac si, nghe co ve trinh trong, khach sao qua. Bach Yen la vo cua Nguyen Kim Hung, cung khoa toi! NKH hien cung dang o My.
Do pH cua Sua Me thay doi theo thoi gian sau sanh (cho bu hoac khong cho bu cung khac nhau). Colostrum co do pH hoi cao (kiem), sau do, giam dan trong 3 thang dau (acid hon), roi lai cao dan len (kiem). Co le do la ly do tai sao vai ba thang dau sau khi sanh, be bu sua me di tieu phan mem, loang, lon nhon, co mau xanh, co mui chua chua…
(The mean pH decreased from 7.45 for colostrum to a nadir of 7.04 during the second week of lactation. Thereafter, the pH of milk remained between 7.0 and 7.1 until 3 months postpartum and then increased gradually to 7.4 by 10 months.)
Chuc anh va gia dinh nhieu suc khoe.
Than men,
DHN.

1 From the Houston Perinatal Nutrition Laboratory and Analytical Chemistry Center, Departments of Pediatrics and of Biochemistry and Molecular Biology, Medical School, The University of Texas Health Science Center at Houston

Human milk pH was measured in 309 samples obtained from 52 women who had delivered at term and lactated for as long as 10 months thereafter. The mean pH decreased from 7.45 for colostrum to a nadir of 7.04 during the second week of lactation. Thereafter, the pH of milk remained between 7.0 and 7.1 until 3 months postpartum and then increased gradually to 7.4 by 10 months. The change in hydrogen ion concentration in milk was associated with corresponding changes throughout lactation in the concentration of citrate but not with the concentration of lactose. Lactose concentration increased gradually for 3 weeks; the concentration of saturated medium-chain fatty acids increased more rapidly. One interpretation of these findings is that the hydrogen ions and citrate generated by mammary secretory cell metabolism are used after the second week of lactation for de novo synthesis of fatty acids more rapidly than they are synthesized. Milk samples from ruminants were found to have concentrations of hydrogen ions and citrate that are greater than and pH that is less than the respective measurements in human milk. The significance for the recipient infant of the predictable changes in human milk pH during lactation and of the higher pH of human milk throughout lactation relative to bovine milk is unknown. However, drug excretion into milk, milk enzyme activity, milk leukocyte function, and neonatal gastroin-testinal function are affected by ambient pH and may be influenced by the pH of milk.

Key Words: citrate • fatty acid • lactose • human milk • pH

Submitted on February 19, 1985
Accepted on December 16, 1985